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Computer science has historically presented barriers for non-native English speaking (NNES) students, often due to language and terminology challenges. With the rise of large language models (LLMs), there is potential to leverage this technology to support NNES students more effectively. Recent implementations of LLMs as tutors in classrooms have shown promising results. In this study, we deployed an LLM tutor in an accelerated introductory computing course to evaluate its effectiveness specifically for NNES students. Key insights for LLM tutor use are as follows: NNES students signed up for the LLM tutor at a similar rate to native English speakers (NES); NNES students used the system at a lower rate than NES students---to a small effect; NNES students asked significantly more questions in languages other than English compared to NES students, with many of the questions being multilingual by incorporating English programming keywords. Results for views of the LLM tutor are as follows: both NNES and NES students appreciated the LLM tutor for its accessibility, conversational style, and the guardrails put in place to guide users to answers rather than directly providing solutions; NNES students highlighted its approachability as they did not need to communicate in perfect English; NNES students rated help-seeking preferences of online resources higher than NES students; Many NNES students were unfamiliar with computing terminology in their native languages. These results suggest that LLM tutors can be a valuable resource for NNES students in computing, providing tailored support that enhances their learning experience and overcomes language barriers. 

Metacognition and self-regulation are important skills for successful learning and have been discussed and researched extensively in the general education literature for several decades. More recently, there has been growing interest in understanding how metacognitive and self-regulatory skills contribute to student success in the context of computing education. This paper presents a thorough systematic review of metacognition and self-regulation work in the context of computer programming and an in-depth discussion of the theories that have been leveraged in some way. We also discuss several prominent metacognitive and self-regulation theories from the literature outside of computing education – for example, from psychology and education – that have yet to be applied in the context of programming education. In our investigation, we built a comprehensive corpus of papers on metacognition and self-regulation in programming education, and then employed backward snowballing to provide a deeper examination of foundational theories from outside computing education, some of which have been explored in programming education, and others that have yet to be but hold much promise. In addition, we make new observations about the way these theories are used by the computing education community, and present recommendations on how metacognition and self-regulation can help inform programming education in the future. In particular, we discuss exemplars of studies that have used existing theories to support their design and discussion of results as well as studies that have proposed their own metacognitive theories in the context of programming education. Readers will also find the article a useful resource for helping students in programming courses develop effective strategies for metacognition and self-regulation. 

For many decades, educational communities, including computing education, have debated the value of telling students what they need to know (i.e., direct instruction) compared to guiding them to construct knowledge themselves (i.e., constructivism). Comparisons of these two instructional approaches have inconsistent results. Direct instruction can be more efficient for short-term performance but worse for retention and transfer. Constructivism can produce better retention and transfer, but this outcome is unreliable. To contribute to this debate, we propose a new theory to better explain these research results. Our theory, multiple conceptions theory, states that learners develop better conceptual knowledge when they are guided to compare multiple conceptions of a concept during instruction. To examine the validity of this theory, we used this lens to evaluate the literature for eight instructional techniques that guide learners to compare multiple conceptions, four from direct instruction (i.e., test-enhanced learning, erroneous examples, analogical reasoning, and refutation texts) and four from constructivism (i.e., productive failure, ambitious pedagogy, problem-based learning, and inquiry learning). We specifically searched for variations in the techniques that made them more or less successful, the mechanisms responsible, and how those mechanisms promote conceptual knowledge, which is critical for retention and transfer. To make the paper directly applicable to education, we propose instructional design principles based on the mechanisms that we identified. Moreover, we illustrate the theory by examining instructional techniques commonly used in computing education that compare multiple conceptions. Finally, we propose ways in which this theory can advance our instruction in computing and how computing education researchers can advance this general education theory. 

Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this publication we describe enhancements made to our data processing pipeline and to our website to adapt to an ever-increasing information content. The number of sequences in UniProtKB has risen to over 227 million and we are working towards including a reference proteome for each taxonomic group. We continue to extract detailed annotations from the literature to update or create reviewed entries, while unreviewed entries are supplemented with annotations provided by automated systems using a variety of machine-learning techniques. In addition, the scientific community continues their contributions of publications and annotations to UniProt entries of their interest. Finally, we describe our new website (https://www.uniprot.org/), designed to enhance our users’ experience and make our data easily accessible to the research community. This interface includes access to AlphaFold structures for more than 85% of all entries as well as improved visualisations for subcellular localisation of proteins. 

Abstract The Gene Ontology (GO) knowledgebase (http://geneontology.org) is a comprehensive resource concerning the functions of genes and gene products (proteins and noncoding RNAs). GO annotations cover genes from organisms across the tree of life as well as viruses, though most gene function knowledge currently derives from experiments carried out in a relatively small number of model organisms. Here, we provide an updated overview of the GO knowledgebase, as well as the efforts of the broad, international consortium of scientists that develops, maintains, and updates the GO knowledgebase. The GO knowledgebase consists of three components: (1) the GO—a computational knowledge structure describing the functional characteristics of genes; (2) GO annotations—evidence-supported statements asserting that a specific gene product has a particular functional characteristic; and (3) GO Causal Activity Models (GO-CAMs)—mechanistic models of molecular “pathways” (GO biological processes) created by linking multiple GO annotations using defined relations. Each of these components is continually expanded, revised, and updated in response to newly published discoveries and receives extensive QA checks, reviews, and user feedback. For each of these components, we provide a description of the current contents, recent developments to keep the knowledgebase up to date with new discoveries, and guidance on how users can best make use of the data that we provide. We conclude with future directions for the project. 

Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.